Author

Dallas B. Flies

ORCID 0000-0002-9280-2080Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

David B. SykesiD· 1 shared Ella P. DennisiD· 1 shared F. ZengiD· 1 shared Jennifer MunkleyiD· 1 shared Kirsty HodgsoniD· 1 shared Liancheng Lu· 1 shared Libby BlencoeiD· 1 shared Margarita Orozco‐MorenoiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCancer Biology

David B. SykesORCID

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1 paper

Recent·Most cited

Siglec-15 is a glyco-immune checkpoint in prostate cancer regulating immune evasion and metastasis

Nicoll Matthews, F. Zeng, Kirsty Hodgson, Matthew Fisher, Ziqian Peng, Libby Blencoe, Margarita Orozco‐Moreno, Ella P. Dennis, Liancheng Lu, Michelle Anne Lawson, Shenglin Mei, David B. Sykes, Dallas B. Flies, Richard Beatson, Ning Wang, Jennifer Munkley

Siglec-15 is found on prostate tumour cells, macrophages and osteoclasts; antibody blockade reduced macrophage immunosuppression, osteoclast formation and tumour growth in mice (CD8+ T-cell-dependent).

bioRxiv · Aug 10, 2026 · PreprintCancer Biology✦ In-depth digest