Michelle Anne Lawson

Personalised prediction of anomalous bone regeneration in multiple myeloma patients

This study develops computational models to predict bone regeneration in multiple myeloma patients using patient data and genomics, showing rapid strengthening not fully explained by known mechanisms.

Siglec-15 is a glyco-immune checkpoint in prostate cancer regulating immune evasion and metastasis

Siglec-15 is found on prostate tumour cells, macrophages and osteoclasts; antibody blockade reduced macrophage immunosuppression, osteoclast formation and tumour growth in mice (CD8+ T-cell-dependent).

Siglec-engaging immunosuppressive sialoglycans are upregulated in prostate cancer and are targetable to suppress bone metastasis

This study identifies Siglec-engaging sialoglycans as upregulated in prostate cancer and shows they can be targeted to suppress bone metastasis using a bisialidase.

Metastatic infiltration of nervous tissue and periosteal nerve sprouting in multiple myeloma induced bone pain

This study identifies periosteal nerve sprouting and DRG metastasis in MM-induced bone pain, linking these changes to pain mechanisms and suggesting neuroprotective strategies.