Rushad Pavri

The paper shows that specific DNA replication origins are still used and excess MCM2-7 is loaded in ORC-deficient human cancer cells.

This study shows RIF1 regulates early replication timing and origin activity in B cells by interacting with MCM proteins, influencing gene replication without major effects on gene expression or genome organization.

The paper shows that a de novo TAD boundary formed by transcriptional activity at acceptor S regions facilitates synapsis during antibody class switch recombination.

This study shows DNA replication timing regulates oncogenic chromosomal translocations by affecting DSB ligation, independent of DSB frequency.