Tobias Neumann

This study shows RIF1 regulates early replication timing and origin activity in B cells by interacting with MCM proteins, influencing gene replication without major effects on gene expression or genome organization.

This study shows DNA replication timing regulates oncogenic chromosomal translocations by affecting DSB ligation, independent of DSB frequency.

The paper investigates chromosomal contacts between promoters and enhancers using Capture Hi-C, showing that cohesin depletion affects long-range contacts but not shorter-range ones.

SLAM-ITseq enables transcriptome analysis of specific cell types in tissues without prior sorting, providing accurate in vivo transcriptional snapshots.

SLAM-seq enables RNA polymerase II-dependent gene expression dynamics analysis by detecting 4-thiouridine incorporation at single-nucleotide resolution in mouse embryonic stem cells.