Irene M. Ong

Farm exposure is associated with human breast milk immune profile and microbiome

The paper compares immune profiles and microbiomes of breast milk from mothers with different farm exposures to identify associations with immune development and atopic disease.

A shark variable new antigen receptor recognizes an occluded epitope of fibroblast activation protein

This study identifies a shark-derived VNAR that binds a hidden epitope on FAP, revealing structural insights for multiepitope targeting strategies.

A Novel Syngeneic Mouse Model to Study Immune Evasion in Head and Neck Squamous Cell Carcinoma

This paper develops a novel syngeneic mouse model for HNSCC to study immune evasion and evaluates its response to immunotherapies.

Exclusive liquid repellency isolation (ELRi) microliter scale isolation technique unmasks T-cell migration defects to CCL21 in pediatric asthma

ELRi isolates immune cells from small blood samples, revealing impaired T-cell migration to CCL21 in pediatric asthma.

A Head and Neck Cancer Patient-Specific Microphysiological System for Predicting Response to Chemoradiation

This paper develops a patient-specific microphysiological system to predict chemoradiation response in head and neck cancer by reconstructing tumor microenvironment complexity.

Priming versus propagating: distinct immune effects of an alpha- versus beta-particle emitting radiopharmaceutical when combined with immune checkpoint inhibition

This study compares the immune effects of alpha- and beta-particle emitting radiopharmaceuticals combined with immune checkpoint inhibitors in murine tumor models, finding distinct mechanisms of action based on radiation type.

Dietary isoleucine content defines the metabolic and molecular response to a Western diet

This study shows that reducing dietary isoleucine improves metabolic health in mice on a Western diet, with distinct molecular responses across sexes and strains.

MPAC: a computational framework for inferring pathway activities from multi-omic data

MPAC infers pathway activities from multi-omic data to identify patient subgroups and clinically relevant proteins, demonstrating improved results over single-omic analyses in head and neck cancer.

Low Dose Radiation by Radiopharmaceutical Therapy Enhances GD2 TRAC-CAR T Cells Efficacy in Localized Neuroblastoma

This paper shows that low-dose radiopharmaceutical therapy enhances GD2 TRAC-CAR T cell efficacy in neuroblastoma by improving tumor regression and immune response.

Ranking Antibody Binding Epitopes and Proteins Across Samples from Whole Proteome Tiled Linear Peptides

The paper introduces HERON, an R package for identifying immunogenic epitopes from ultradense peptide binding arrays across multiple samples.

MASH Native: A Unified Solution for Native Top-Down Proteomics Data Processing

MASH Native provides a unified software solution for processing native top-down proteomics data, offering database searching and analysis tools in a user-friendly interface.