This study examines the association between multiple self-reported health behaviors and cognitive decline in a cohort of non-demented middle-aged individuals, finding limited significant associations.

PLoS ONE · Apr 23, 2020Peer-reviewedNeuroscience

Age-accelerated cognitive decline in asymptomatic adults with CSF β-amyloid

Lindsay R. Clark, Sara Elizabeth Berman, Derek Norton, Rebecca L. Koscik, Erin McMullen Jonaitis, Kaj Blennow, Barbara B. Bendlin, Sanjay Asthana, Sterling C. Johnson, Henrik Zetterberg, Cynthia M. Carlsson

The paper compares cognitive and hippocampal volume decline in asymptomatic adults with and without CSF β-amyloid or tau markers, finding accelerated decline in those with positive markers.

Neurology · Mar 9, 2018Peer-reviewedNeuroscience

Modifiable risk factors moderate the relationship between amyloid and cognition in midlife

Lindsay R. Clark, Rebecca L. Koscik, Samantha L. Allison, Sara Elizabeth Berman, Cynthia M. Carlsson, Derek Norton, Barbara B. Bendlin, Sanjay Asthana, Tobey J. Betthauser, Bradley T. Christian, Sterling C. Johnson

This study shows that hypertension and depression, but not obesity, moderate the link between amyloid and cognitive decline in midlife individuals at risk for Alzheimer's disease.

bioRxiv · Jan 23, 2018 · PreprintNeuroscience

The Wisconsin Registry for Alzheimer’s Prevention: A Review of findings and current directions

Sterling C. Johnson, Rebecca L. Koscik, Erin McMullen Jonaitis, Lindsay R. Clark, Kimberly Diggle Mueller, Sara Elizabeth Berman, Barbara B. Bendlin, Corinne D. Engelman, Ozioma C. Okonkwo, Kirk J. Hogan, Sanjay Asthana, Cynthia M. Carlsson, Bruce P. Hermann, Mark A. Sager

The paper reviews findings from the Wisconsin Registry for Alzheimer’s Prevention, highlighting associations between genetic and lifestyle factors and early AD pathophysiology.

Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · Dec 8, 2017Peer-reviewedNeuroscience