Dominik von Elverfeldt

This study investigates the immunomodulatory effects of SHP2-based vertical RAS pathway inhibition in pancreatic cancer, revealing both immune-activating and suppressive changes that evolve with treatment.

This study shows that dual SHP2/MEK inhibition in pancreatic cancer causes mitochondrial changes and ROS elevation, leading to a therapy-resistant state that can be targeted with GPX4 inhibition.

The paper identifies genomic and transcriptomic changes associated with chromosomal instability and seasonal brain size plasticity in the Eurasian common shrew.

The paper analyzes gene expression in the pancreas of Aselli of the common shrew to assess its role in plasma cell differentiation and compares it to spleen and bursa of Fabricius.

The paper compares gene expression in captive and wild shrew brains, finding hundreds of differentially expressed genes linked to neurodegenerative pathways and ribosomal proteins.

This study identifies seasonal gene expression changes in shrew hypothalamus linked to brain size plasticity and compares them to human neurological disorders.

The paper examines metabolic and molecular changes in Sorex araneus during seasonal shrinkage, identifying shifts in oxidative phosphorylation, fatty acid metabolism, and FOXO signaling.

This study investigates brain-wide responses to hippocampal electrical stimulation in a mouse model of mesial temporal lobe epilepsy using fMRI, finding that stimulation frequency, not amplitude, determines the extent of activation spread.

The paper compares structural and functional brain connectivity between C57BL/6 and BALB/cJ mice using MRI techniques, revealing strain-specific differences in brain morphology and connectivity patterns.

The paper uses DTI to analyze microstructural changes in the P301L mouse model of tauopathy, finding gene-dose dependent effects in white and grey matter.

This study identifies reproducible resting-state networks in the mouse brain across multiple centers using standardized rsfMRI analysis.