Jan Klohs

This paper develops a harmonized MRI QC framework using phantoms to identify sources of variability across field strengths and sites, showing that field strength alone does not fully characterize MRI performance.

This study finds no difference in hippocampal mGluR5 levels between Alzheimer's and control brains, but shows amyloid and tau have opposing effects on mGluR5 in controls.

The paper uses PET and MSOT to observe hypoxia and increased spinal cord metabolism in tMCAO mice compared to sham-operated mice.

This paper demonstrates noninvasive transcranial MSOT angiography in a human volunteer and validates its anatomical alignment with MRI.

This study evaluates CB2R expression and pyridine-based radiotracers in a mouse model of Alzheimer's disease, finding increased CB2R in glial cells but no significant mRNA differences.

This study identifies a biphasic inflammatory response after intracerebral hemorrhage, with an early MyD88-TLR4-dependent activation of the choroid plexus preceding secondary inflammation and leukocyte infiltration.

This paper demonstrates a 3D visualization method for amyloid-beta deposits in Alzheimer's mouse models using MRI and FMT, showing improved depth resolution compared to 2D methods.

The paper investigates AQP4 distribution and depolarization in tau and amyloid-beta pathologies using mouse models and imaging techniques.

This paper demonstrates non-invasive whole brain imaging of tau deposits using vMSOT and PBB5 probe in P301L mice, showing specific binding and retention in tau-laden regions.

This study uses PET and MRI to assess CB2R levels and metabolic changes in a mouse model of cerebral ischemia, finding increased CB2R and reduced glucose metabolism in the ischemic striatum.

This paper characterizes CRANAD-2 for detecting amyloid-beta deposits in Alzheimer's mouse models using multi-spectral optoacoustic tomography and fluorescence imaging.

This study detects cerebral tauopathy in P301L mice using large-field multifocal illumination fluorescence microscopy and a fluorescent ligand, showing increased probe retention in affected mice.

The paper reports intracranial calcification in P301L mice associated with tau pathology and bone protein deposits, using MRI and micro-CT imaging.

The paper examines structural connectivity and network topology in ArcAβ mice, finding disrupted connectivity and reduced network efficiency linked to Aβ amyloidosis.

The paper introduces vMSOT with AOI987 to quantify Aβ deposition in AD mouse models, revealing strain-specific patterns.

This paper introduces a transcranial fluorescence microscopy technique to detect amyloid-beta plaques in mouse models of Alzheimer's disease at single-plaque resolution across the entire brain.

The paper uses DTI to analyze microstructural changes in the P301L mouse model of tauopathy, finding gene-dose dependent effects in white and grey matter.