Roger M. Nitsch

Peripheral T-cell co-signalling states mark vulnerability and resilience to cerebral Aβ pathology

The paper identifies T-cell co-signalling states linked to vulnerability and resilience to cerebral Aβ pathology in Alzheimer's disease.

Multiscale brain-wide mapping of α-synuclein-driven dopaminergic degeneration and white matter impairment in α-synucleinopathy mice

This paper maps α-synuclein pathology and dopaminergic degeneration in mice using multimodal imaging and microscopy, showing spread along the nigrostriatal pathway and microstructural changes.

Targeting integrin αvβ3 by chimeric antigen receptor neural stem cell (CAR-NSC) therapy for stroke

This paper develops CAR-NSC therapy targeting integrin αvβ3 to improve spatial distribution and tissue engagement of transplanted cells in stroke models.

Neural xenografts contribute to long-term recovery in stroke via molecular graft-host crosstalk

This study shows that transplanting iPSC-derived neural progenitor cells improves long-term recovery after stroke in mice by promoting tissue repair and reducing neurological deficits.

Altered T cell reactivity to β-amyloid-related antigens in early Alzheimer's disease

The paper examines immune changes in early Alzheimer's disease stages, finding altered T cell reactivity to β-amyloid-related antigens in preclinical AD and MCI.

Reduced levels of synaptic vesicle protein 2A in the extracellular vesicles and brain of Alzheimer's disease- associations with Aβ, tau and synaptophysin

The paper examines reduced SV2A levels in AD brain tissue and extracellular vesicles, linking them to amyloid-β, tau, and synaptic markers.

Hippocampal mGluR5 levels are comparable in Alzheimer's and control brains, and divergently influenced by amyloid and tau in control brain

This study finds no difference in hippocampal mGluR5 levels between Alzheimer's and control brains, but shows amyloid and tau have opposing effects on mGluR5 in controls.

Spinal cord perfusion impairments in the M83 mouse model of Parkinson's disease

The paper uses multimodal imaging to assess spinal cord oxygenation and vascular changes in a PD mouse model, finding reduced oxygen saturation but no vascular impairment or atrophy.

Hippocampal purinergic P2X7 receptor level is increased in Alzheimer's disease patients, and associated with amyloid and tau pathologies

The paper examines increased P2X7R levels in Alzheimer's disease hippocampi, correlating with amyloid and tau pathologies, and identifies its potential as a neuroinflammation marker.

Relationship between reactive astrocytes, by SMBT-1 imaging, with amyloid-beta, tau, glucose metabolism, and microgliosis in mouse models of Alzheimer's disease

Visualizing alpha-synuclein and iron deposition in M83 mouse model of Parkinson's disease in vivo

The paper visualizes alpha-synuclein inclusions and iron deposition in M83 mouse models of Parkinson's disease using in vivo imaging and ex vivo validation techniques.

Analysis of skull thickness, scalp-to-cortex distance and association with age and sex in cognitively normal elderly

The paper develops an automatic pipeline for analyzing skull thickness and scalp-to-cortex distance from MRI data and shows age and sex-related changes in these metrics in elderly individuals.

Coregistered transcranial optoacoustic and magnetic resonance angiography of the human brain

This paper demonstrates noninvasive transcranial MSOT angiography in a human volunteer and validates its anatomical alignment with MRI.

Comprehensive preclinical evaluation of human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease

This study evaluates human-derived anti-poly-GA antibodies in cellular and animal models of C9ORF72 disease, showing mixed effects on poly-GA levels and disease progression.

Xeno-free induced pluripotent stem cell-derived neural progenitor cells for in vivo applications

This paper develops xeno-free iPSC-derived NPCs compatible with GMP for clinical use, showing long-term survival and differentiation into neurons in vivo.

Aquaporin 4 is differentially increased and depolarized in association with tau and amyloid-beta

The paper investigates AQP4 distribution and depolarization in tau and amyloid-beta pathologies using mouse models and imaging techniques.

Non-invasive imaging of tau-targeted probe uptake by whole brain multi-spectral optoacoustic tomography

This paper demonstrates non-invasive whole brain imaging of tau deposits using vMSOT and PBB5 probe in P301L mice, showing specific binding and retention in tau-laden regions.

APOE2, E3 and E4 differentially modulate cellular homeostasis, cholesterol metabolism and inflammatory response in isogenic iPSC-derived astrocytes

This study shows APOE alleles E2, E3, and E4 differentially affect astrocyte metabolism, cholesterol handling, and inflammation in isogenic iPSC-derived cells, with E4 showing disease-relevant dysregulation.

Nutrient signaling pathways regulate amyloid clearance and synaptic loss in Alzheimer's disease

This study identifies nutrient signaling pathways that regulate amyloid clearance and synaptic loss in Alzheimer's disease, showing both protective and harmful effects.

Tau deposition is associated with imaging patterns of tissue calcification in the P301L mouse model of human tauopathy

The paper reports intracranial calcification in P301L mice associated with tau pathology and bone protein deposits, using MRI and micro-CT imaging.

Whole brain optoacoustic tomography reveals strain-specific regional beta-amyloid densities in Alzheimer`s disease amyloidosis models

The paper introduces vMSOT with AOI987 to quantify Aβ deposition in AD mouse models, revealing strain-specific patterns.

Transcranial in vivo detection of Aβ at single plaque resolution with large-field multifocal illumination fluorescence microscopy

This paper introduces a transcranial fluorescence microscopy technique to detect amyloid-beta plaques in mouse models of Alzheimer's disease at single-plaque resolution across the entire brain.

DTI reveals whole-brain microstructural changes in the P301L mouse model of tauopathy

The paper uses DTI to analyze microstructural changes in the P301L mouse model of tauopathy, finding gene-dose dependent effects in white and grey matter.