Carola A. Haas

Long-term hippocampal low-frequency stimulation alleviates focal seizures, memory deficits and synaptic pathology in epileptic mice

PEACOC - Detecting and classifying a wide range of epileptiform activity patterns in rodents

PEACOC detects and classifies diverse epileptiform activity patterns in rodents, revealing a continuum of spike loads and an anti-correlation with granule cell dispersion.

Focal cortical dysplasia type II-dependent maladaptive myelination in the human frontal lobe

This study examines myelination patterns in FCD IIa and IIb in the frontal lobe, finding divergent maladaptive myelination features between the two subtypes.

Low frequency stimulation for seizure suppression: identification of optimal targets in the entorhinal-hippocampal circuit

This study identifies presynaptic targets in the entorhinal-hippocampal circuit that effectively suppress seizures using low-frequency stimulation in a mouse model of MTLE.

Probing hippocampal stimulation in experimental temporal lobe epilepsy with functional MRI

This study investigates brain-wide responses to hippocampal electrical stimulation in a mouse model of mesial temporal lobe epilepsy using fMRI, finding that stimulation frequency, not amplitude, determines the extent of activation spread.

On-demand low-frequency stimulation for seizure control: efficacy and behavioral implications

This study evaluates on-demand low-frequency stimulation for seizure control in a mouse model of mesial temporal lobe epilepsy, showing improved efficacy and no cognitive deficits.

Differential vulnerability of neuronal subpopulations of the subiculum in a mouse model for mesial temporal lobe epilepsy

The paper identifies cell loss and subtype-specific vulnerability of interneurons in the subiculum of a mouse model for mesial temporal lobe epilepsy.

Comprehensive multiomic profiling of somatic mutations in malformations of cortical development

This study identifies 69 mutated genes in malformations of cortical development using multiomic profiling of 317 brain resections and single-cell sequencing.

In vivo characterization and application of a novel potassium channel-based optogenetic silencer in the healthy and epileptic mouse hippocampus

The paper develops and tests a novel optogenetic silencer, PACK, in healthy and epileptic mice, finding it effectively inhibits neuronal activity but causes side effects.

Transcriptional characterization of the glial response due to chronic neural implantation of flexible microprobes

This study characterizes the transcriptional response of glial cells to chronic implantation of flexible microprobes over 18 weeks, showing initial activation and eventual partial normalization.