James M. A. Turner

This study uses CRISPR-Cas9 in opossums to show RSX is required for initiating X-inactivation, with divergent Polycomb regulation compared to eutherians.

The paper generates isogenic hiPSCs with controlled sex chromosomes to study sex differences and X-haploinsufficiency effects on gene expression.

This study generates the first single-cell transcriptomic atlas of marsupial gastrulation and early organogenesis, revealing accelerated transcriptional programs and novel tissues associated with developmental heterochrony.

The paper introduces Icebear, a neural network framework for cross-species imputation and comparison of single-cell transcriptomic profiles, revealing evolutionary adaptations of X-chromosome upregulation in mammals.

The paper investigates PADI6's role in oocyte cytoplasmic lattices using single-cell proteomics and transcriptomics, revealing its critical scaffolding function and connections to other oocyte compartments.

This study identifies Y-chromosome gene functions in mouse spermatogenesis by generating Y-deletion models and analyzing gene effects on fertility.

This study shows sex chromosomes significantly shape the transcriptional landscape of preimplantation mouse embryos through various mechanisms including Y chromosome effects, X chromosome dosage, imprinting, and Xist.

The paper identifies an X-Y translocation in Four-Core Genotypes mice that increases Tlr7 expression and affects genetic interpretation.

This study identifies TAF4b-regulated transcription networks in mouse oocytes, revealing its role in meiosis, chromatin structure, and X-linked gene expression.

This study shows that multiple 9-1-1 complexes are essential for meiotic DSB repair, homolog synapsis, and ATR signaling in mammals.

The paper analyzes single-cell genomics and transcriptomics data from CRISPR-Cas9-edited human embryos to assess unintended editing outcomes and loss-of-heterozygosity.

The paper develops CRISPR-Cas9 tools to generate all-male mouse litters by targeting the Topoisomerase 1 gene with a bicomponent system.