Hervé Moine

The DGKK mRNA is a primary target of the Prader-Willi syndrome-associated snoRNA SNORD116

The paper identifies DGKK as the primary target of SNORD116, showing increased DGKK RNA and protein levels upon SNORD116 depletion in human and mouse models.

m⁶A-dependent FMRP control of DGKκ translation underlies core Fragile X phenotypes

The paper identifies DGKκ as a key target of FMRP regulation through m⁶A modification, showing its role in FXS phenotypes.

Comparative analysis of PDZ-binding motifs in the diacylglycerol kinase family

The paper identifies functional differences in PDZ-binding motifs among DGK enzyme types using interactomic and evolutionary analyses.

AAV-delivery of diacylglycerol kinase kappa achieves long-term rescue of Fmr1-KO mouse model deficits of fragile X syndrome

AAV-delivered FMRP-independent DGKk corrects brain lipid homeostasis and behavioral deficits in Fmr1-KO mice.

Pioglitazone improves deficits of Fmr1-KO mouse model of Fragile X syndrome by interfering with excessive diacylglycerol signaling

This study shows pioglitazone reduces excessive diacylglycerol signaling in Fmr1-KO mice, improving behavioral deficits associated with Fragile X syndrome.