Luc Négroni

The paper identifies a proteomic signature in extracellular vesicles from tumor-draining veins of NSCLC patients that may serve as prognostic biomarkers for relapse.

This study quantifies how mutations in GATA1 affect DNA binding affinity using a new assay, revealing that certain mutations reduce binding while others increase it.

The paper identifies DGKκ as a key target of FMRP regulation through m⁶A modification, showing its role in FXS phenotypes.

The paper identifies novel IRE1 interactors that regulate its RNase activity and stability, revealing new functions in the unfolded protein response.

This study identifies GOLIM4 as a downstream target of IRE1/XBP1s that regulates protein secretion, affecting glioblastoma cell adhesion and migration.

This study shows that partially assembled TFIID complexes can initiate RNA polymerase II transcription but cannot fully replace holo-TFIID over time.

The paper identifies functional differences in PDZ-binding motifs among DGK enzyme types using interactomic and evolutionary analyses.

This study shows that ATAC and SAGA coactivator complexes assemble co-translationally in the cytoplasm, but their localization and functions differ.

The paper introduces nHU, a method to quantify binding affinities from cell extracts, showing agreement between in vitro and in-cell measurements.

The paper measures affinities of 65,000 PDZ domain interactions using quantitative fragmentomics, revealing viral interference hotspots and system-wide impacts of interactome hijacking.

This study shows that USP22 and ATXN7L3 are essential for mouse development, with distinct roles, and that H2Bub1 deubiquitylation does not globally regulate RNA polymerase II transcription.

The paper shows that the TBPL2/TFIIA complex establishes the oocyte transcriptome by using a specific TSS recognition code through oocyte-specific promoter usage.