Kimberly P. Luttik

This study uses longitudinal single-nucleus RNA sequencing to analyze transcriptional dynamics in SCA1 cerebellum, identifying early cellular changes and applying deep learning to predict disease state.

This study shows that reducing Nemo-like kinase enhances lysosome biogenesis and improves TDP-43 clearance, alleviating neurodegeneration in mouse models.

This study investigates the differential effects of Wnt-β-catenin signaling in Purkinje cells and Bergmann glia in SCA1, showing distinct cellular responses to enhanced signaling in disease models.

The paper identifies genetic loci influencing binge-like eating in mice using a cross between C57BL/6J and DBA/2J strains, finding sex-specific and combined QTLs.

This study investigates the role of Hnrnph1 in fentanyl-induced behaviors, finding reduced sensitivity and reward in mutants with sex-specific effects.

The paper identifies 5' UTR variants in Hnrnph1 that reduce 5' UTR usage and hnRNP H protein levels, linking these changes to reduced methamphetamine sensitivity.

This study identifies a mutation in Hnrnph1 that reduces methamphetamine-induced reinforcement, reward, and dopamine release while increasing synaptic hnRNP H and mitochondrial proteins in mice.

The paper examines changes in hnRNP H localization in primary rat cortical neurons after D1 dopamine receptor activation, finding increased nuclear immunostaining of the C-terminal domain without changes in protein levels.