Author

Yiran Guo

Children's Hospital of PhiladelphiaORCID 0000-0002-6266-9186Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 3 Genetic & Genomic Medicine· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Approach:statistical model· 4 Assay:DNA methylation· 2 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Allan S. KaplaniD· 3 shared Andrew W. BergeniD· 3 shared Craig Johnson· 3 shared Fernando Fernández‐ArandaiD· 3 shared Hakon H. HakonarsoniD· 3 shared Harry Brandt· 3 shared Katherine Ann HalmiiD· 3 shared Philip A. P. M. GorwoodiD· 3 shared

Activity by Year

2018-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetic & Genomic Medicine

Allan S. KaplanORCID

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5 papers

Recent·Most cited

Genetic & Genomic MedicineBiological PsychiatryPeer-reviewedSep 8, 2021

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

Niamh Mullins, Jooeun Kang, Adrián I. Campos…·DAVID L. BRAFF

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

238 citationstop 1%

humanGWAS summary statistics

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GeneticsProceedings of the National Academy of SciencesPeer-reviewedJul 16, 2020

Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation

Wendan Ren, Huitao Fan, Sara A. Grimm…·Jikui Song

This study identifies the RFTS domain of DNMT1 as a reader for H3K9me3/H3Ub, showing its role in DNA methylation maintenance and genomic stability.

116 citationstop 3%

humanDNA methylation

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GeneticsNature CommunicationsPeer-reviewedJul 3, 2020

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms

Linfeng Gao, Max Emperle, Yiran Guo…·Jikui Song

This study characterizes the structure-function differences between DNMT3A and DNMT3B, revealing distinct mechanisms of de novo DNA methylation and their implications in epigenomic alterations.

199 citationstop 1%

humanDNA methylation

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GenomicsNature GeneticsPeer-reviewedApr 27, 2020

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson's Disease

Julien Bryois, Nathan Skene, Thomas Folkmann Hansen…·Jaakko A. Kaprio

This study identifies cell types associated with brain complex traits using GWAS and single-cell transcriptomics, revealing novel roles for oligodendrocytes in Parkinson's disease.

368 citationstop 1%

humanbulk RNA-seq

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GeneticsbioRxivPreprintFeb 14, 2018

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

Laura M. Huckins, Amanda L. Dobbyn, Whitney C. McFadden…·Mario Maj

This paper uses transcriptomic imputation to identify gene-tissue associations linked to Anorexia Nervosa risk, finding significant links in both brain and metabolic tissues.

3 citations

humanGWAS summary statistics

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