This paper conducts a multi-ancestry GWAS meta-analysis of suicide attempt, identifying 12 genome-wide significant loci and finding shared genetic risks with ADHD, smoking, and risk tolerance.

medRxiv · Jul 3, 2022 · PreprintGenetic & Genomic Medicine

Dissecting the shared genetic architecture of suicide attempt, psychiatric disorders and known risk factors

Niamh Mullins, Jooeun Kang, Adrián I. Campos, Jonathan R. I. Coleman, Alexis C. Edwards, Hanga Galfalvy, Daniel F. Levey, Adriana Lori, Andrey A. Shabalin, Anna Starnawska, Mei-Hsin Su, Hunna J. Watson, Mark J. Adams, Swapnil Awasthi, Michael J. Gandal, , DAVID L. BRAFF

This study identifies genetic loci associated with suicide attempts and shows shared genetic architecture with psychiatric disorders and non-psychiatric risk factors.

Biological Psychiatry · Sep 8, 2021Peer-reviewedGenetic & Genomic Medicine

Genetic Identification of Cell Types Underlying Brain Complex Traits Yields Novel Insights Into the Etiology of Parkinson's Disease

Julien Bryois, Nathan Skene, Thomas Folkmann Hansen, Lisette J. A. Kogelman, Hunna J. Watson, Zijing Liu, Roger A.H. Adan, Lars S. Alfredsson, Tetsuya Ando, Ole A. Andreassen, Jessica H. Baker, Andrew W. Bergen, Wade H. Berrettini, Andreas Birgegård, Joseph M. Boden, , Jaakko A. Kaprio

This study identifies cell types associated with brain complex traits using GWAS and single-cell transcriptomics, revealing novel roles for oligodendrocytes in Parkinson's disease.

Nature Genetics · Apr 27, 2020Peer-reviewedGenomics

Shared Genetic Risk between Eating Disorder- and Substance-Use-Related Phenotypes: Evidence from Genome-Wide Association Studies

Melissa A. Munn‐Chernoff, Emma C. Johnson, Yi‐Ling Chou, Jonathan R. I. Coleman, Laura M. Thornton, Raymond Kenney Walters, Zeynep Yılmaz, Jessica H. Baker, Christopher Hübel, Scott D. Gordon, Sarah Elizabeth Medland, Hunna J. Watson, Héléna A. Gaspar, Julien Bryois, Anke Hinney, , Maria C. La Via

The paper estimates genetic correlations between eating disorder and substance-use-related phenotypes using GWAS data, finding both positive and negative associations.

Addiction Biology · Feb 16, 2020Peer-reviewedGenetics

Identifying tissues implicated in Anorexia Nervosa using Transcriptomic Imputation

Laura M. Huckins, Amanda L. Dobbyn, Whitney C. McFadden, Douglas M. Ruderfer, Weiqing Wang, Eric R. Gamazon, Virpi Leppä, Roger A.H. Adan, Tetsuya Ando, Jessica H. Baker, Andrew W. Bergen, Wade Berrettini, Andreas Birgegård, Claudette Boni, Vesna Boraska Perica, , Mario Maj

This paper uses transcriptomic imputation to identify gene-tissue associations linked to Anorexia Nervosa risk, finding significant links in both brain and metabolic tissues.

bioRxiv · Feb 14, 2018 · PreprintGenetics