Non-canonical inflammasome drives intrinsic anti-microbial responses in human Natural Killer (NK) cells.
Nathan Georges François Leborgne, Jadie Acklam, Alexander J. Hogg, Zarema Albakova, Karen G. Hogg, Kim S. Robinson, Grant M. Calder, Arnel Junior Villamin, Callum Robson, Freya Pealing, Matthew A. Care, Monika Gońka, James M. Fox, James Iremonger, Frances Elizabeth Pearson, , Dave Boucher
This study identifies a non-canonical inflammasome in human NK cells that mediates anti-microbial responses against Salmonella without canonical inflammasome components.
bioRxiv · Oct 20, 2025 · PreprintImmunology