Dave Boucher

This study identifies a novel mechanism by which caspase-4 and -5 interact with executioner caspases-3 and -7 to enable pyroptosis-apoptosis crosstalk, enhancing inflammatory responses.

This study identifies a non-canonical inflammasome in human NK cells that mediates anti-microbial responses against Salmonella without canonical inflammasome components.

This study identifies DtpT as the primary dipeptide transporter in Staphylococcus aureus and reveals its role in glutathione uptake, enhancing bacterial survival in macrophages.

This study shows that CASP1 self-cleavage terminates its activity in vivo, maintaining homeostasis and preventing inflammasome-driven diseases.

This study shows that β-glucan induces trained innate immunity in macrophages, reducing their efferocytosis of cancer cells and altering inflammatory responses.