Matthew A. Care

This study identifies a non-canonical inflammasome in human NK cells that mediates anti-microbial responses against Salmonella without canonical inflammasome components.

This study shows that enforced MYC expression alters transcriptional programs and metabolic shifts during human plasma cell differentiation without causing transformation.

The paper uses cisREAD to integrate chromatin accessibility and gene expression data from B cell differentiation, showing a shift from PU.1/SPIB to AP-1 driven gene regulation during activation.

The paper defines common gene co-expression principles across cancers to improve molecular stratification by identifying consistent expression modules and their associations with mutation states.