Vaishali Sanchorawala

The paper uses cryo-EM to analyze lambda-6 light chain amyloid structures from different organs and patients, revealing structural diversity and potential interactions with collagen-VI.

The paper reports a cryo-EM structure of cardiac AL-224L amyloid and identifies shared structural features across {lambda}6-LC amyloid folds.

The paper identifies early molecular and functional signatures in cardiac AL amyloidosis patients with abnormal GLS and reduced inflammatory markers despite no significant amyloid fibril deposition.

The paper updates the AL-Base database and identifies enriched immunoglobulin light chain variable genes in AL amyloidosis, showing some genes are highly enriched and others have mutation patterns distinct from other conditions.