Author

Brian Spencer

Boston UniversityORCID 0000-0002-2182-5170Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:cryo-EM· 2 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Sherry WongiD· 3 shared Tatiana B. ProkaevaiD· 3 shared Vaishali SanchorawalaiD· 3 shared Chad W. HicksiD· 2 shared Francesca LavatelliiD· 2 shared Hui A. CheniD· 2 shared Noorul HudaiD· 2 shared Olga GurskyiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersBiophysics

Sherry WongORCID

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3 papers

Recent·Most cited

Cryo-EM reveals patient- versus organ-specific structural diversity and bound ligands in lambda-6 light chain amyloids

Noorul Huda, Brian Spencer, Chad W. Hicks, Shobini Jayaraman, George Anthony Pantelopulos, Sherry Wong, Hui A. Chen, Robert B. Best, Vaishali Sanchorawala, Francesca Lavatelli, Tatiana B. Prokaeva, Olga Gursky

The paper uses cryo-EM to analyze lambda-6 light chain amyloid structures from different organs and patients, revealing structural diversity and potential interactions with collagen-VI.

bioRxiv · Aug 28, 2026 · PreprintBiophysics

Cryo-EM of cardiac AL-224L amyloid reveals shared features in {lambda}6 light chain fibril folds

Chad W. Hicks, Tatiana B. Prokaeva, Brian Spencer, Shobini Jayaraman, Noorul Huda, Sherry Wong, Hui A. Chen, Vaishali Sanchorawala, Francesca Lavatelli, Olga Gursky

The paper reports a cryo-EM structure of cardiac AL-224L amyloid and identifies shared structural features across {lambda}6-LC amyloid folds.

bioRxiv · Jun 25, 2025 · PreprintBiophysics

An updated AL-Base reveals ranked enrichment of immunoglobulin light chain variable genes in AL amyloidosis

Gareth J. Morgan, Allison N. Nau, Sherry Wong, Brian Spencer, Yun Shen, Axin Hua, Matthew J. Bullard, Vaishali Sanchorawala, Tatiana B. Prokaeva

The paper updates the AL-Base database and identifies enriched immunoglobulin light chain variable genes in AL amyloidosis, showing some genes are highly enriched and others have mutation patterns distinct from other conditions.

Amyloid · Dec 6, 2024Peer-reviewedBioinformatics