Jommel Macaraeg

This study functionally characterizes mutant ASXL1 in human hematopoietic stem cells, showing it drives transcriptional activation and repression through interactions with BRD4 and MECOM, with implications for therapy.

The paper characterizes mutations in C. elegans Haspin homologs, showing hasp-1's roles in germline stem cell proliferation, spermatogenesis, and oocyte meiosis, with genetic interactions involving plk-2 and CPC recruitment pathways.