Mutant ASXL1 Drives Transcriptional Activation and Repression in Human Hematopoiesis
Madison L. Hall, Aliya Quintal, Samantha J. Worme, T. Nguyen, Zachary Schonrock, Mitsuhiro Tsuchiya, Sonia N. Acharya, Hanqian L. Carlson, Itallia V. Pacentine, Shawn B. Shrestha, Jommel Macaraeg, Randall J. Armstrong, James C. McGann, Sara Evans-Dutson, Theresa A. Lusardi, , Theodore P. Braun
This study functionally characterizes mutant ASXL1 in human hematopoietic stem cells, showing it drives transcriptional activation and repression through interactions with BRD4 and MECOM, with implications for therapy.
bioRxiv · Jan 14, 2026 · PreprintCancer Biology