Theodore P. Braun

This study identifies stem-monocytic AML as a distinct subtype resistant to venetoclax and shows that PU.1 inhibition synergizes with BCL2 blockade to enhance therapeutic response.

This study functionally characterizes mutant ASXL1 in human hematopoietic stem cells, showing it drives transcriptional activation and repression through interactions with BRD4 and MECOM, with implications for therapy.

This study identifies MYST acetyltransferases as therapeutic targets in SETBP1-mutant leukemia, showing that MYST inhibitors reduce target gene expression and improve survival in mouse models.

sciMET-cap reduces sequencing burden for single-cell methylation analysis while enabling accurate cell type assignment and near-complete methylome reconstruction.

This paper introduces Priori, a method to predict transcription factor activity from RNA sequencing data, showing it outperforms existing methods in detecting aberrant activity and identifying disease-related factors.

CITE-Viz is a visualization tool for CITE-Seq data that replicates flow cytometry gating workflows to enable cell cluster classification and multi-omic analysis.

GoPeaks is a peak calling method for CUT&Tag data that improves sensitivity in detecting H3K27Ac peaks compared to standard algorithms.