Paul Donlin-Asp

The paper investigates SynGAP1's local translation during synaptic plasticity, finding that its synthesis is transiently suppressed during LTP induction, opposing the current model of SynGAP1 dispersion.

The paper investigates how long-term potentiation and depression differentially regulate mRNA dynamics and translation in neurons.

Proteasome inhibition leads to reduced neuronal protein synthesis through stabilization and enhanced translation of HRI kinase, which is constitutively active due to low neuronal heme levels.

The paper demonstrates that local protein synthesis occurs in both pre- and postsynaptic compartments of neurons, including excitatory and inhibitory axon terminals.