Claudia M. Fusco

The paper shows that ribosome biogenesis factors and pre-rRNA processing enzymes are present in distal neuronal compartments, suggesting local ribosome maturation occurs in dendrites.

The paper identifies co-translational assembly domains in proteins that facilitate interactions between nascent chains and fully synthesized subunits, revealing their role in regulating complex assembly pathways.

The paper shows that neuronal ribosomal proteins dynamically exchange in a context-dependent manner, independent of canonical ribosome biogenesis.

The paper quantifies the spatial scale of synaptic protein allocation during homeostatic plasticity and finds that proteins are distributed at the level of synaptic neighborhoods.

Proteasome inhibition leads to reduced neuronal protein synthesis through stabilization and enhanced translation of HRI kinase, which is constitutively active due to low neuronal heme levels.