Polymerase Evolution Enables Access to Glycosylated Xeno-Nucleic Acids with Expanded Chemical Functionality
Eloi Vincent, Victoria A. Maola, Clement Lopez, Marc Borie-Guichot, Maria Dalla Pozza, Mohammad Hajjar, Rémi Sieskind, Soizick Lucas‐Staat, Rafael Navaza, Laurence A. Mulard, Marcel Hollenstein, John Charles Chaput, Marc H. Delarue
This paper evolves a DNA polymerase to synthesize glycosylated xeno-nucleic acids with base and backbone modifications, enabling new chemical functionality in genetic polymers.
bioRxiv · Jul 21, 2026 · PreprintSynthetic Biology