The paper presents cryo-EM structures of phage A-family DNA polymerases fused to a uracil-DNA glycosylase domain, revealing their role in reading dU bases and repairing abasic sites during replication.

Nucleic Acids Research · Oct 24, 2026Peer-reviewedMolecular Biology

Polymerase Evolution Enables Access to Glycosylated Xeno-Nucleic Acids with Expanded Chemical Functionality

Eloi Vincent, Victoria A. Maola, Clement Lopez, Marc Borie-Guichot, Maria Dalla Pozza, Mohammad Hajjar, Rémi Sieskind, Soizick Lucas‐Staat, Rafael Navaza, Laurence A. Mulard, Marcel Hollenstein, John Charles Chaput, Marc H. Delarue

This paper evolves a DNA polymerase to synthesize glycosylated xeno-nucleic acids with base and backbone modifications, enabling new chemical functionality in genetic polymers.

bioRxiv · Jul 21, 2026 · PreprintSynthetic Biology

Mechanisms Ensuring Fidelity of Family X DNA Polymerases in Programmed DNA rearrangements in Paramecium tetraurelia

Antonin Nourisson, Sophia Missoury, Soizick Lucas‐Staat, Ahmed Haouz, Marc H. Delarue

The paper investigates how DNA polymerases in Paramecium tetraurelia ensure high fidelity during programmed DNA rearrangements by analyzing structural changes in polymerase lambda mutants.

Nucleic Acids Research · Jul 31, 2025Peer-reviewedBiochemistry