Steen Larsen

The divergent effects of nicotinamide riboside and high-intensity exercise training on skeletal muscle epigenetic aging

This study examines how NR supplementation and HIIT affect skeletal muscle epigenetic aging, finding opposing effects on epigenetic age acceleration across different clocks.

Rac1 deficiency reduces mitochondrial respiratory capacity, impairs fatty acid metabolism and causes muscle wasting

This study shows that Rac1 deficiency in muscle reduces mitochondrial function and fatty acid metabolism, leading to muscle wasting and highlights potential therapeutic targets for age-related muscle decline.

Acyl-CoA Binding Protein in White and Brown Adipose Tissue is Dispensable for Systemic Energy Metabolism

This study shows that ACBP is not essential for adipose tissue function or systemic energy metabolism in mice, as knockout mice show no significant metabolic changes.

Pathophysiological remodeling of the skeletal muscle microenvironment in patients with lung cancer

The paper investigates muscle remodeling in NSCLC patients, identifying changes in fibro-adipogenic progenitors, mitochondrial function, and immune cells that contribute to muscle wasting.

Insulin stimulated upregulation of OCTN2 carnitine transporters is impaired in patients with Primary carnitine deficiency

This study investigates whether hyperinsulinemia enhances L-carnitine uptake in PCD patients and finds that insulin stimulates OCTN2 translocation in controls but not in PCD patients, with no significant increase in skeletal muscle carnitine levels in PCD.

Dysregulated Skeletal Muscle Myosin Super-relaxation and Energetics in Type II Diabetes

This study investigates altered myosin super-relaxation and energy metabolism in type II diabetes using muscle biopsies and proteomic analyses, finding increased super-relaxation and reduced ATP demand.

Housing temperature dictates the systemic and tissue specific molecular responses to cancer in mice

This study shows that housing temperature affects molecular and systemic responses to cancer in mice, influencing metabolic adaptations and cytokine levels.

The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms

This study identifies SLIRP as a mitochondrial mRNA stabilizing protein that regulates mitochondrial structure and respiration in skeletal muscle, with exercise improving mitochondrial function through increased mitoribosome capacity.

AMPK is elevated in human cachectic muscle and prevents cancer-induced metabolic dysfunction in mice

This study shows that AMPK is upregulated in human cachectic muscle and that AMPK deficiency in mice worsens cancer-induced metabolic dysfunction and cachexia.