Author

Mingdong Zhang

Karolinska InstitutetORCID 0000-0002-6348-1994Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Patrik ErnforsiD· 3 shared Dmitry UsoskiniD· 2 shared Jie SuiD· 2 shared Jussi KupariiD· 2 shared Laura Calvo-EnriqueiD· 2 shared Yizhou HuiD· 2 shared Abdeljabbar El ManiraiD· 1 shared Alejandro GonzáleziD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Patrik ErnforsORCID

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3 papers

Recent·Most cited

Neural ensembles that encode affective mechanical and heat pain in mouse spinal cord

Mingdong Zhang, Jussi Kupari, Jie Su, Kajsa A. Magnusson, Yizhou Hu, Laura Calvo-Enrique, Dmitry Usoskin, Gioele W. Albisetti, Mikaela M. Ceder, Katharina Henriksson, Andrew D. Leavitt, Hanns Ulrich Zeilhofer, Tomas G. M. Hökfelt, Malin Charlotta Lagerström, Patrik Ernfors

The paper identifies distinct neural ensembles in mouse spinal cord encoding mechanical and heat pain and shows their role in affective pain behavior.

Nature Neuroscience · Mar 24, 2025Peer-reviewedNeuroscience

Persistent interferon signaling that causes sensory neuron plasticity and pain in arthritis

Jie Su, Mingdong Zhang, Jussi Kupari, Dongoh Kwak, Laurence D. Picton, Bingze Xu, Yizhou Hu, Alejandro González, Dmitry Usoskin, Zhongwei Xu, Abdeljabbar El Manira, Rikard Holmdahl, Patrik Ernfors

The paper identifies persistent interferon signaling via the MNK1/2-eIF4E pathway as a driver of sensory neuron plasticity and pain in arthritis.

bioRxiv · Jan 18, 2025 · PreprintNeuroscience

Sensory Schwann cells set perceptual thresholds for touch and selectively regulate mechanical nociception

Julia Ojeda‐Alonso, Laura Calvo-Enrique, Ricardo Paricio-Montesinos, Rakesh Kumar, Ming-Dong Zhang, James F.A. Poulet, Patrik Ernfors, Gary R. Lewin

This study identifies sensory Schwann cells as critical for mechanosensation, showing they regulate touch and mechanical nociception.

Nature Communications · Feb 6, 2024Peer-reviewedNeuroscience