Patrik Ernfors

The paper shows that TRPV1+ afferents rapidly reprogram TRPV1- Aβ afferents, leading to hyperalgesia in humans.

This paper constructs a human dorsal root ganglion reference atlas, identifying 22 neuronal subtypes and 10 non-neuronal cell types, and reveals functional differences between human and mouse DRG neurons.

The paper identifies distinct neural ensembles in mouse spinal cord encoding mechanical and heat pain and shows their role in affective pain behavior.

The paper identifies persistent interferon signaling via the MNK1/2-eIF4E pathway as a driver of sensory neuron plasticity and pain in arthritis.

This study develops a method to sequence individual human DRG neuron somas, identifies 16 neuronal types, and reveals human-specific nociceptor types and potential drug targets.

This study identifies sensory Schwann cells as critical for mechanosensation, showing they regulate touch and mechanical nociception.

The paper identifies primate sensory neuron types associated with human chronic pain using transcriptomics and maps human pain heritability to these neuronal types.

The paper uses single-cell RNA-sequencing to define 12 molecularly distinct enteric neuron classes in mice and identifies their developmental trajectories and regulatory mechanisms.

The paper identifies a genetic variant in KCNG4 associated with increased labor pain by altering KV6.4 function in uterine nociceptors.

This study shows that PADI2-mediated citrullination is essential for oligodendrocyte differentiation, myelination, and motor function, with implications for remyelination therapies.

The paper maps cell types in the mouse nervous system using single-cell RNA sequencing and identifies distinct astrocyte and oligodendrocyte subtypes with specific molecular and spatial characteristics.