Tomas G. M. Hökfelt

Aberrant microglial responses shape hypothalamic circuits in anorexia nervosa

The paper investigates microglial dysfunction in anorexia nervosa using patient-derived iPSCs and an animal model, finding altered synaptic interactions and signaling in hypothalamic circuits.

Neural ensembles that encode affective mechanical and heat pain in mouse spinal cord

The paper identifies distinct neural ensembles in mouse spinal cord encoding mechanical and heat pain and shows their role in affective pain behavior.

Heterosynaptic Plasticity of the Visuo-auditory Projection Requires Cholecystokinin released from Entorhinal Cortex Afferents

This study shows that heterosynaptic plasticity in the visuo-auditory projection requires CCK released from entorhinal cortex afferents to form associative memory.

Expression of substance P, NPY and their Receptors Is Altered in Major Depression

The paper examines changes in substance P, NPY, and their receptors in major depression by analyzing transcript levels in brain regions of suicide victims and controls.

Genome-wide single cell annotation of the human protein-coding genes

The paper annotates all human protein-coding genes with their function and spatial distribution across cell types using single-cell transcriptomics data and introduces a new classification tool.

Developmental time course of SNAP-25 isoform regulation of hippocampal long-term synaptic plasticity and hippocampus-dependent learning

This study investigates how different SNAP-25 isoforms regulate synaptic plasticity and learning in the hippocampus across development and adulthood.

Brain-wide genetic mapping identifies the indusium griseum as a prenatal and shared target of pharmacologically-unrelated psychostimulants

The paper identifies the indusium griseum as a prenatal target of psychostimulants and shows that Scgn+/Vglut1+ neurons in this region are critical for neuronal excitability and linked to behavioral abnormalities.