Co-Targeting IL-6 and EGFR signaling for the treatment of schwannomatosis and associated pain
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, John W. Chen, Sonu Subudhi, William W. Ho, Grace Y. Lee, Athena Ching‐Jung Wang, Xing Gao, Jun P. Ren, Chao Zhu, Na Zhang, Gino B. Ferraro, Alona Muzikansky, , Lei Xu
This study identifies IL-6 and EGFR signaling as therapeutic targets for schwannomatosis, showing combined blockade reduces both pain and tumor growth in preclinical models.
bioRxiv · Feb 6, 2023 · PreprintNeuroscience