Author

Oleg A. Sineshchekov

The University of Texas Health Science Center at HoustonORCID 0000-0002-6358-7764Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Elena G. GovorunovaiD· 2 shared François St-PierreiD· 2 shared Hai LiiD· 2 shared John L. SpudichiD· 2 shared Mingshan XueiD· 2 shared Yueyang GouiD· 2 shared Alex James McDonaldiD· 1 shared Alyssa Palmateer· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersNeuroscience

Elena G. GovorunovaORCID

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2 papers

Recent·Most cited

A highly Ca2+-permeable channelrhodopsin from the ancyromonad Nutomonas longa enables optogenetic control of Ca2+ signaling

Elena G. Govorunova, Yueyang Gou, Alex James McDonald, Oleg A. Sineshchekov, Hai Li, Y Wang, François St-Pierre, Mingshan Xue, John L. Spudich

This paper identifies NlCCR, a channelrhodopsin from Nutomonas longa, which enables precise optical control of Ca2+ signaling with improved properties compared to existing tools.

bioRxiv · Jul 27, 2026 · PreprintNeuroscience

Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics

Elena G. Govorunova, Oleg A. Sineshchekov, Hai Li, Yueyang Gou, Hongmei Chen, Shuyuan Yang, Yumei Wang, Stephen Mitchell, Alyssa Palmateer, Leonid S. Brown, François St-Pierre, Mingshan Xue, John L. Spudich

The paper identifies blue-shifted channelrhodopsins from ancyromonads that enable multiplex optogenetics by conducting chloride or cation currents with improved spectral properties.

eLife · Sep 19, 2025Peer-reviewedBiochemistry