This study examines how changes in kynurenine pathway metabolite ratios relate to antidepressant response in patients treated with SSRIs, finding specific shifts in neuroprotective-to-neurotoxic metabolite balances.

bioRxiv · Jan 11, 2025 · PreprintNeuroscience

Role of enhanced glucocorticoid receptor sensitivity in inflammation in PTSD: Insights from a computational model for circadian-neuroendocrine-immune interactions

Pramod Rajaram Somvanshi, Synthia H. Mellon, Rachel Yehuda, Janine Dyck Flory, Linda M. Bierer, Iouri Makotkine, Charles R. Marmar, Marti Jett, Francis J. Doyle

The paper develops a computational model to explore how increased glucocorticoid receptor sensitivity in PTSD contributes to inflammation through HPA-axis and immune system interactions.

American Journal of Physiology-Endocrinology and Metabolism · Apr 21, 2020Peer-reviewedSystems Biology

Mechanistic insights on metabolic dysfunction in PTSD: Role of glucocorticoid receptor sensitivity and energy deficit

Pramod Rajaram Somvanshi, Synthia H. Mellon, Janine Dyck Flory, Duna Abu Amara, Owen M. Wolkowitz, Rachel Yehuda, Marti Jett, Charles R. Marmar, Francis J. Doyle, Leroy Hood, Kai Wang, Inyoul Lee, Rasha Hammamieh, Aarti Gautam, Bernie J. Daigle, Ruoting Yang

The paper uses a systems biology approach to analyze how glucocorticoid receptor sensitivity and energy deficit contribute to metabolic dysfunction in PTSD.

bioRxiv · Dec 17, 2018 · PreprintSystems Biology

Cortisol Predicts Antidepressant Treatment Outcome, Memory Improvement, and Brain Response to Negative Emotions: The Importance of Aging

Felipe A. Jain, Colm G. Connolly, Victor I. Reus, Dieter J. Meyerhoff, Tony T. Yang, Synthia H. Mellon, Scott Mackin, Christina M. Hough, Alexandra Morford, Elissa S. Epel, Owen M. Wolkowitz

This study shows that age moderates how cortisol levels relate to depression diagnosis, treatment response, and brain activity to negative emotions.

bioRxiv · Oct 22, 2018 · PreprintPhysiology