The paper examines polygenic risk scores for PTSD severity and chronicity in World Trade Center responders, finding significant genetic contributions and associations with brain imaging phenotypes.

medRxiv · Dec 6, 2020 · PreprintGenetic & Genomic Medicine

Role of enhanced glucocorticoid receptor sensitivity in inflammation in PTSD: Insights from a computational model for circadian-neuroendocrine-immune interactions

Pramod Rajaram Somvanshi, Synthia H. Mellon, Rachel Yehuda, Janine Dyck Flory, Linda M. Bierer, Iouri Makotkine, Charles R. Marmar, Marti Jett, Francis J. Doyle

The paper develops a computational model to explore how increased glucocorticoid receptor sensitivity in PTSD contributes to inflammation through HPA-axis and immune system interactions.

American Journal of Physiology-Endocrinology and Metabolism · Apr 21, 2020Peer-reviewedSystems Biology

Genomic Influences on Self-Reported Childhood Maltreatment

Shareefa Dalvie, Adam X. Maihofer, Jonathan R. I. Coleman, Bekh Bradley, Gerome D. Breen, Leslie Ann D. Brick, Chia‐Yen Chen, Karmel W. Choi, Laramie E. Duncan, Guia Guffanti, Magali Haas, Supriya Harnal, Israel Liberzon, Nicole R. Nugent, Allison C. Provost, , Caroline M. Nievergelt

This study identifies genetic variants associated with self-reported childhood maltreatment and finds significant genetic correlations with depressive symptoms.

Translational Psychiatry · Jan 27, 2020Peer-reviewedGenomics

Mechanistic insights on metabolic dysfunction in PTSD: Role of glucocorticoid receptor sensitivity and energy deficit

Pramod Rajaram Somvanshi, Synthia H. Mellon, Janine Dyck Flory, Duna Abu Amara, Owen M. Wolkowitz, Rachel Yehuda, Marti Jett, Charles R. Marmar, Francis J. Doyle, Leroy Hood, Kai Wang, Inyoul Lee, Rasha Hammamieh, Aarti Gautam, Bernie J. Daigle, Ruoting Yang

The paper uses a systems biology approach to analyze how glucocorticoid receptor sensitivity and energy deficit contribute to metabolic dysfunction in PTSD.

bioRxiv · Dec 17, 2018 · PreprintSystems Biology

Largest genome-wide association study for PTSD identifies genetic risk loci in European and African ancestries and implicates novel biological pathways

Caroline M. Nievergelt, Adam X. Maihofer, Torsten Klengel, Elizabeth G. Atkinson, Chia‐Yen Chen, Karmel W. Choi, Jonathan R. I. Coleman, Shareefa Dalvie, Laramie E. Duncan, Mark W. Logue, Allison C. Provost, Andrew D. Ratanatharathorn, Murray B. Stein, Katy Torres, Allison E. Aiello, , Douglas Maurer

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

bioRxiv · Nov 1, 2018 · PreprintGenetics