Victor I. Reus

Rare coding variation implicates thirteen genes in bipolar disorder across 232,536 individuals from global populations

A founder population reveals genetic variation with major effect on serious mental illness

The paper identifies a founder variant in ADAP1 associated with increased risk of schizophrenia and bipolar disorder in a Colombian genetic isolate.

Analysis of Rare Coding Variation Identifies New Genetic Contributors to Schizophrenia

Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.

Effect of ancestry and shared genetic architecture of serious mental illness on symptoms and cognition in an admixed Latin American population

The paper shows that European GWAS findings for serious mental illness and cognition are portable to an admixed Latin American population, associating genetic risk scores with multiple symptoms and cognitive traits.

Kynurenine Metabolism is Associated with Antidepressant Response to Selective Serotonin Reuptake Inhibitors

This study examines how changes in kynurenine pathway metabolite ratios relate to antidepressant response in patients treated with SSRIs, finding specific shifts in neuroprotective-to-neurotoxic metabolite balances.

Distinct and shared contributions of diagnosis and symptom domains to cognitive performance in a case-control study of severe mental illness in the Paisa population

The paper investigates how diagnosis and symptom domains affect cognitive performance in a case-control study of severe mental illness, finding distinct cognitive profiles linked to specific symptom domains.

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates

This study examines genetic risk for bipolar disorder in extended families, finding that both common and rare variants contribute to susceptibility, with no significant segregation of large-effect variants.

Understanding the Hidden Complexity of Latin American Population Isolates

The paper analyzes genomic diversity in Latin American population isolates, finding increased genetic diversity and consanguinity compared to the Finnish isolate.

Cortisol Predicts Antidepressant Treatment Outcome, Memory Improvement, and Brain Response to Negative Emotions: The Importance of Aging

This study shows that age moderates how cortisol levels relate to depression diagnosis, treatment response, and brain activity to negative emotions.