Emily Zhi-Yun Keung

Cross-species Study of Canine and Human Peripheral Nerve Sheath Tumors: Clinical and Molecular Perspectives

This study compares canine and human peripheral nerve sheath tumors, finding that H3K27me3 loss and H3K27ac gain drive tumor progression in both species.

Spatially-Resolved Multiomic Atlas of Leiomyosarcoma Identifies Two Clinically Relevant Epigenetically-Driven Cell States

This study identifies two epigenetically distinct cell states in leiomyosarcoma using single-nucleus multiome sequencing and spatial transcriptomics, linking them to clinical outcomes and therapeutic vulnerabilities.

Spatially-resolved single cell atlas of liposarcoma reveals lineage hierarchies, immune niches, and regulatory circuits

This study uses single-nucleus multiome sequencing and spatial transcriptomics to analyze liposarcoma subtypes, revealing distinct cellular states, immune features, and gene regulatory circuits.

ATRX Loss Predicts Poor Outcomes and Reveals a Therapeutic Vulnerability to TEAD Inhibition in Soft Tissue Sarcomas

This study shows ATRX loss in sarcomas correlates with poor outcomes and identifies TEAD inhibition as a potential therapy for ATRX-deficient tumors.