William J. Janssen

This study shows that amoxicillin use during influenza A infection increases mortality and worsens secondary bacterial pneumonia, particularly in males.

This paper shows tobramycin increases Mycobacterium abscessus survival by inducing whiB7, which enhances resistance to oxidative stress and macrophage killing.

This study shows that amoxicillin causes long-term gut dysbiosis and reduces type-17 immune tone in the lungs.

This study shows that Siglec-F protects against elastase-induced lung inflammation and emphysema by regulating airspace macrophages in mice.

This study shows that Siglec-F deficiency reduces fibrosis in bleomycin-induced lung injury by altering gene expression in airspace macrophages.

This study identifies and characterizes the anatomical distribution of human lung macrophage subpopulations using single-cell RNA sequencing and finds smoking-induced changes in their accumulation patterns.

This study identifies fucosyltransferase 2 (Fut2) as essential for mucin fucosylation, which contributes to allergic airway hyperreactivity and mucus obstruction in mice.