Author

James C. Needell

University of Colorado Anschutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Christopher M. EvansiD· 3 shared Naoko Hara· 3 shared William J. JansseniD· 3 shared Ana Maria JaramilloiD· 2 shared Marika OrloviD· 2 shared Alexandra L. McCubbreyiD· 1 shared Anna Q. Harder· 1 shared Ayako KatoiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersPhysiology

Christopher M. EvansORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Amoxicillin induces gut dysbiosis leading to long term suppression of type-17 immune tone in the lungs

Marika Orlov, Mallory Karr, Naoko Hara, James C. Needell, Carol M. Aherne, Jennifer L. Matsuda, Brent E. Palmer, Catherine Lozupone, S E Clark, William J. Janssen, Christopher M. Evans

This study shows that amoxicillin causes long-term gut dysbiosis and reduces type-17 immune tone in the lungs.

bioRxiv · Mar 9, 2026 · PreprintImmunology

Siglec-F Deficiency Prevents Fibrosis After Bleomycin-Induced Acute Lung Injury

Marika Orlov, Naoko Hara, Sunad Rangarajan, Ana Maria Jaramillo, Qihua Ye, Yuliana Maritza Romo-Perez, Kenny Ngo, James C. Needell, Anna Q. Harder, Fan Jia, Brian E. Vestal, Rachel Z. Blumhagen, Tingting Tu, Jazalle D. McClendon, Alexandra L. McCubbrey, , Christopher M. Evans

This study shows that Siglec-F deficiency reduces fibrosis in bleomycin-induced lung injury by altering gene expression in airspace macrophages.

American Journal of Respiratory Cell and Molecular Biology · Jul 30, 2025Peer-reviewedPhysiology

Requirement for Fucosyltransferase 2 in Allergic Airway Hyperreactivity and Mucus Obstruction

Naoko Hara, Dorota S. Raclawska, Leslie E. Morgan, James C. Needell, Lucie Dao, Ayako Kato, Ana Maria Jaramillo, Patrick S. Hume, Fernando Holguín, William J. Janssen, Eszter K. Vladar, Christopher M. Evans

This study identifies fucosyltransferase 2 (Fut2) as essential for mucin fucosylation, which contributes to allergic airway hyperreactivity and mucus obstruction in mice.

American Journal of Respiratory Cell and Molecular Biology · Oct 24, 2024Peer-reviewedPhysiology