Elizabeth A. Wynn

The paper introduces REBEL, a method for analyzing differential expression in longitudinal scRNA-seq data, showing it controls false discovery rate and has competitive power.

This study identifies and characterizes the anatomical distribution of human lung macrophage subpopulations using single-cell RNA sequencing and finds smoking-induced changes in their accumulation patterns.

This study investigates the physiologic recovery of Mycobacterium tuberculosis in mice after antibiotic treatment, finding that recovery is slow, sequential, and incomplete, with longer treatment leading to slower recovery.

The paper uses SEARCH-TB to analyze drug interactions in M. tuberculosis by measuring transcriptional responses to the BPaL regimen in vivo, showing complex effects of drug combinations.

This study examines how prolonged antibiotic treatment affects M. tuberculosis physiology in mice, finding that sterilizing and non-sterilizing antibiotics induce distinct transcriptional responses.

The paper introduces RESCUE, a method to simulate longitudinal scRNA-seq data, incorporating between-sample and between-subject variability, and demonstrates its use in study planning.