Molecular BiologybioRxivPreprint
Reductive death is averted by an ancient metabolic switch.
Fasih M. Ahsan, Jen F. Rotti, Armen I. Yerevanian…·Alexander A. Soukas
The paper identifies reductive stress as a toxicity of biguanides like metformin, showing that fatty acid biosynthesis protects against this effect and could be targeted in cancer.
DOI 10.1101/2025.11.24.690166