Author

Jen F. Rotti

Harvard UniversityORCID 0009-0002-8044-2134Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Organism:multiple species· 1

Frequent Co-Authors

Alexander A. SoukasiD· 2 shared Armen I. YerevanianiD· 2 shared Fasih M. AhsaniD· 2 shared Nicole L. StuhriD· 2 shared Sinclair W. EmansiD· 2 shared Daniel J. BakeriD· 1 shared Dimitra PouliiD· 1 shared Jose A. Aceves-SalvadoriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMolecular Biology

Alexander A. SoukasORCID

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2 papers

Recent·Most cited

Reductive death is averted by an ancient metabolic switch.

Fasih M. Ahsan, Jen F. Rotti, Armen I. Yerevanian, Sinclair W. Emans, Nicole L. Stuhr, Jose A. Aceves-Salvador, Wei Wang, Daniel J. Baker, Dimitra Pouli, Owen S. Skinner, Michael D. Blower, Alexander A. Soukas

The paper identifies reductive stress as a toxicity of biguanides like metformin, showing that fatty acid biosynthesis protects against this effect and could be targeted in cancer.

bioRxiv · Nov 24, 2025 · PreprintMolecular Biology

Ribosomal RNA Synthesis is a Lethal Vulnerability During Reductive Stress In C. elegans

Jen F. Rotti, Fasih M. Ahsan, Nicole L. Stuhr, Sinclair W. Emans, Alexander A. Soukas, Armen I. Yerevanian

This study identifies that impaired ribosomal RNA biogenesis enhances resistance to reductive stress in C. elegans by reducing NADPH/NADH accumulation and GSH levels.

bioRxiv · Nov 24, 2025 · PreprintGenetics