Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomes
Eamon Fitzgerald, Mojun Shen, Hannah E. J. Yong, Zihan Wang, Irina Pokhvisneva, Sachin H Patel, Nicholas O’Toole, Shiao‐Yng Chan, Yap Seng Chong, Helen Chen, Peter David Gluckman, Jerry Kok Yen Chan, Patrick Kia Ming Lee, Michael Joseph Meaney
The paper defines a homeostatic inflammation signature in the placenta, creates a polygenic score, and shows its protective effects on cardiovascular and depressive outcomes using UK Biobank data.
medRxiv · Feb 20, 2023 · PreprintGenetic & Genomic Medicine