Shiao-yng Chan

Long-read transcriptome assembly reveals vast transcriptional complexity in the placenta associated with metabolic and endocrine function

The paper uses long-read RNA-seq to create a comprehensive placental transcriptome reference, revealing high transcriptional complexity and identifying novel isoforms associated with metabolic and endocrine functions in gestational diabetes.

Natural variation in transplacental transfer efficiency exposes distinct transcriptional network architectures of PFAS effects on birth weight and gestational age

The paper shows PFAS affect birth weight and gestational age through distinct transcriptional network architectures, with network position, not fold-change, determining mediator importance.

Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomes

The paper defines a homeostatic inflammation signature in the placenta, creates a polygenic score, and shows its protective effects on cardiovascular and depressive outcomes using UK Biobank data.