Helen Chen

Assessment of ecological fidelity of human microbiome-associated mice in observational studies and an interventional trial

This study evaluates the ecological fidelity of HMA mice in replicating human microbiome responses to a microbial consortium, finding they are more similar to other mice than their human donors.

Patient derived model of UBA5-associated encephalopathy identifies defects in neurodevelopment and highlights potential therapies

The paper develops a patient-derived cortical organoid model of UBA5-associated encephalopathy, identifies neurodevelopmental defects, and highlights potential therapeutic strategies.

Homeostatic inflammation in the placenta is protective against adult cardiovascular and depressive outcomes

The paper defines a homeostatic inflammation signature in the placenta, creates a polygenic score, and shows its protective effects on cardiovascular and depressive outcomes using UK Biobank data.

Microglial function moderates the relation between depression risk factors and depression outcomes across the life course in females

The paper shows that microglial function influences how depression risk factors affect depression outcomes differently in females compared to males across the life course.