Jie Shen

This study identifies Cloche/Npas4l as a pro-regenerative platelet factor in zebrafish heart regeneration, showing its role in regulating cardiomyocyte and endothelial cell proliferation through ligand-receptor interactions.

This study identifies shared genetic loci and genes between PTSD and cardiovascular conditions using GWAS across multiple data sources and finds overlapping biological pathways and drug targets.

This study identifies 51 anxiety-associated genetic loci from a multi-ancestry GWAS of 1.2 million participants and highlights genetic correlations with other mental and physical health conditions.

The paper introduces SPRINTseq, a spatial transcriptomics method that enables fast, sensitive, and high-resolution data acquisition, revealing cellular and subcellular molecular architecture in Alzheimer's disease.

SHERRY2 is a single-cell RNA sequencing protocol that improves sensitivity and accuracy by eliminating second-strand cDNA synthesis, outperforming existing methods in detecting low-abundance transcripts and specific gene functions.

The paper uses single-cell whole genome sequencing to identify low frequency somatic copy number alterations in normal human lymphocytes, finding 7.5% of cells have large-size copy number alterations.