Dirk C. Hoffmann

The paper shows brain metastases form gap-junction-coupled networks with coordinated calcium activity that drives proliferation and is inhibited by gap junction blockers.

The paper introduces molecular recorders to track kinase activity in cells and applies them to study PKA activity and neuromodulation.

This study uses single-cell multiomics to identify regulatory programs and plasticity regulators in glioblastoma, revealing MYT1L as a key repressor of malignant plasticity.

This study investigates how high LET particle therapy affects tumor microtube networks in glioblastoma, finding that higher LET reduces TM formation and improves cell survival.