Christabel Mclain

This paper performs a meta-analysis of gene expression data from five datasets to identify long-term effects of early life stress on the prefrontal cortex, finding consistent downregulation of myelin-related genes and upregulation of genes related to Major Depressive Disorder.

The paper shows that early-life stress sensitizes neurons in the nucleus accumbens to reactivate during adult stress, contributing to stress hypersensitivity.

The paper examines oxytocin receptor expression in brain regions affected by intranasal oxytocin and finds higher OXTR expression in affected subcortical regions.