Mechanistic basis for the spatiotemporal assembly of the Bloom Syndrome complex on ultrafine DNA bridges
Umit Aliyaskarova, Özgün Özer, Mahafuzul Sumon, Eleftheria Karanika, Adrijana Crncec, Zuza Kozik, Theodoros I. Roumeliotis, Jyoti Sharma Choudhary, María Fernández-Casañas, M.W. Day, Antony W. Oliver, Jonathon Pines, Kok‐Lung Chan
This study identifies how the BTRR complex assembles on ultrafine DNA bridges through SLiM recognition by RMI1-RMI2, revealing spatiotemporal regulation during DNA repair and segregation.
bioRxiv · Sep 13, 2026 · PreprintCell Biology